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Direct supplementation with Urolithin A overcomes limitations ofdietary exposure and gut microbiome variability in healthy adultsto achieve consistent levels across the population | 1 |
Abstract | 1 |
Introduction | 1 |
Methods | 2 |
Study design and participant demographics | 2 |
Inclusion and exclusion criteria | 2 |
Investigational products and randomization | 2 |
Blood and fecal samples collection | 3 |
UA bioavailability measurements | 4 |
Quantification of ellagic acid, punicalagins, and UA in commercial grade food products and dietary supplements | 4 |
Shotgun metagenomic sequencing and analysis of microbiome | 5 |
Safety assessments | 5 |
Statistical analysis | 5 |
Results | 6 |
Determination of dietary precursor levels in pomegranate-based supplements and juice | 6 |
Compliance to study products and safety | 6 |
The majority of the study population failed to produce UA following dietary exposure to PJ | 6 |
Gut microbiome plays an essential role in defining UA producers | 7 |
UA producer and non-producer exhibit differentially abundant gut microbiome taxa | 8 |
Direct oral supplementation with Urolithin A delivers significantly higher levels than PJ | 8 |
Discussion | 9 |
Compliance with ethical standards | 11 |
ACKNOWLEDGMENTS | 11 |
References | 11 |
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