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Introduction | 1 |
Materials and Methods | 3 |
Peptide Prediction for Bioactivity and Natural Source Identification | 3 |
Natural Peptide Network Production | 3 |
Sample Preparation and Mass Spectrometry Analysis | 4 |
Cell Culture, Differentiation of Monocytes and Inflammation ELISA Assays | 4 |
Human Randomised, Double Blinded, Parallel Group, Placebo Controlled Clinical Trial | 4 |
Participants and Study Design | 4 |
Glucose Tolerance Test | 6 |
Serum Cytokine Concentrations | 6 |
Statistics | 6 |
Results | 7 |
Bioactivity Screening and Rice NPN Characteristics | 7 |
Effects of Constituent Peptides Predicted with Anti-Inflammatory Effects on TNF- Secretion | 8 |
Supplementation with Rice NPN in an Elderly Cohort Had Beneficial Effects on Physical Activity and Correlated with Markers of Age Associated Inflammation | 9 |
Supplementation with Rice NPN Increased Glucose Uptake When Challenged with a Glucose Tolerance Test | 11 |
Rice NPN Supplementation Altered LDL and HDL Serum Concentrations | 13 |
Discussion | 13 |
Conclusions | 15 |
References | 15 |
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