clinical_frontiers revision_clean 050923

Asthma

No AE Reported Possibly related AE Probably related AE

8 0 0 2

72.7

0.0 0.0

Not related AE o

18.2

Lower respiratory tract infection

Unlikely related AE o

1

9.1

Urinary tract infection

Total

11

100.0

358 359

360

361

362

363

364

365

366

367

368

369

Table 3. Paired samples test to assess within group change in lung function parameters from Baseline 370 to Week 4 in the healthy (n=11) and asthma (n=11) populations. 371

Paired Differences

95% Confidence Interval of the Difference

Significance

Mean

SD

SEM

Lower Upper

t

df Two-sided p

Healthy FEV1 Average (%) Week 4 – Baseline Healthy FVC Average (%) Week 4 – Baseline

-5.000

9.110 2.747 -11.120 1.120

-1.820 10 0.099

-2.091

7.661 2.310 -7.238

3.056

-0.905 10 0.387

Healthy FEV1/FVC

-0.036

0.069 0.021 -0.082

0.010

-1.735 10 0.113

12

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