Postbiotics-Research-Guide

paediatric diarrhoea and prevent common in- fectious diseases among young children (Malagón-Rojas et al., 2020). CLINICAL IMPLICATIONS AND METHODS To date, research evidence supports postbiotics’ potential as alternative agents, which may serve as safer options when compared to their parent live cells, and therefore can be applied as prom- ising compounds in the health and food industry (Rad et al., 2020). There is significant potential for the addition of postbiotics to food and health products to bring health benefits to a substantial portion of the population, including those suffering from the certain disease conditions, where they could play a meaningful therapeutic role. However, the suc- cess of postbiotics can depend on a variety of fac- tors, most of which are interrelated. For example, the postbiotic ability to induce a health effect on the individual may be fuelled by a variety of differ- ent processes or pathways, most of which remain unknown or yet unresearched . Also, postbiotics can consist of a complex mixture of bioactive com- ponents, in which characterisation can be limited

by current technologies. To be able to ensure that a commercial postbiotic product retains its prop- erties and other required health-promoting attri- butes effectively, it is crucial to understand the active molecules bringing the beneficial effects to the consumer. Investigations, including pre-clini- cal and clinical testing, need to be carried out in order to identify and isolate the safest and most functional strains responsible for production of the bioactive. Further studies are then needed to determine the optimum target population, the ideal effective dose, and the most efficient form of administration. To date, the research design for studies focusing on postbiotics has provided a great challenge for commercialization of these products (Thorakkattu et al., 2022). To date, no regulatory authorities, have devel- oped a postbiotic concept or framework that is particular to foods or dietary supplements that include postbiotics. For example, the European Food Safety Authority (EFSA) help to regulate the standards for food and are updated on a regular basis; while the European Pharmacopoeia pro- vides defined guidelines that specify maximum

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