CLINICAL TRIALS SUMMARY
Table 2. Summary of the most recently registered clinical trials investigating postbiotc interventions. Participants N Study design Intervention Status
Duration (months)
Patients with Geographic Atrophy Age-Related Macular Degeneration Children with obesity
10 Open label study with dietary intervention 30 Open label study with dietary intervention; phase 4 60 Open label study with dietary intervention 31 Open label study with dietary intervention
Postbiotic with added multivitamin supplement
12
Active, not recruiting
4
Unknown status
Postbiotic Lactobacillus paracasei CNCM I-5220 with added vitamin D3 Postbiotic (cell lysate and DNA fragments of the probiotic strain L. rhamnosus DV - NRRLB-68023 ) Cow’s milk based infant formula containing prebiotics, probiotics and postbiotics
Patients aged between 18 and 70 years of age with type 2 diabetes
3 months (intervention) + 3 months of follow up
Recruiting
Singleton infants aged between 14 and 84 days of age with a gestational age at birth of ≥37 weeks and ≤41 weeks
1
Completed
Patients with macular degeneration
48 A randomized parallel assignment
Postbiotic added with vitamins
12
Recruiting
with quadruple masking study with dietary intervention
Singleton infants aged between 0 days to 17 weeks and with a gestational age at birth of ≥37 weeks and ≤41 weeks
279 A randomised, controlled, double-blind,
Infant formula with prebiotics and postbiotics
17
Completed
parallel study with triple masking
Older healthy adults (females) aged between 50 and 65 years of age
30 Double blinded, placebo controlled, randomised dose response study with triple masking
3
Active, not recruiting
Postbiotic Heat killed and purified Bifidobacterium breve polysaccharide-based extract
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