Postbiotics-Research-Guide

CLINICAL TRIALS SUMMARY

Table 2. Summary of the most recently registered clinical trials investigating postbiotc interventions. Participants N Study design Intervention Status

Duration (months)

Patients with Geographic Atrophy Age-Related Macular Degeneration Children with obesity

10 Open label study with dietary intervention 30 Open label study with dietary intervention; phase 4 60 Open label study with dietary intervention 31 Open label study with dietary intervention

Postbiotic with added multivitamin supplement

12

Active, not recruiting

4

Unknown status

Postbiotic Lactobacillus paracasei CNCM I-5220 with added vitamin D3 Postbiotic (cell lysate and DNA fragments of the probiotic strain L. rhamnosus DV - NRRLB-68023 ) Cow’s milk based infant formula containing prebiotics, probiotics and postbiotics

Patients aged between 18 and 70 years of age with type 2 diabetes

3 months (intervention) + 3 months of follow up

Recruiting

Singleton infants aged between 14 and 84 days of age with a gestational age at birth of ≥37 weeks and ≤41 weeks

1

Completed

Patients with macular degeneration

48 A randomized parallel assignment

Postbiotic added with vitamins

12

Recruiting

with quadruple masking study with dietary intervention

Singleton infants aged between 0 days to 17 weeks and with a gestational age at birth of ≥37 weeks and ≤41 weeks

279 A randomised, controlled, double-blind,

Infant formula with prebiotics and postbiotics

17

Completed

parallel study with triple masking

Older healthy adults (females) aged between 50 and 65 years of age

30 Double blinded, placebo controlled, randomised dose response study with triple masking

3

Active, not recruiting

Postbiotic Heat killed and purified Bifidobacterium breve polysaccharide-based extract

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