Juniper Online Journal of Case Studies
23 08 .41. 76 ma ng dd3o2s e. 8s4 onfmcool l/l ma glefno l hl oywd ri no gl y isnagt ee ,s trieosnp eo cf t3i v0e. 8l y, . 1I5n3g .e8s tai nn dg over 153.8mg of collagen hydrolysate significantly increased the average concentrations of the free and peptide forms of hl i ymdirt owx yaps rnool itnree a icnh e dp l wa simt ha i. n gTehset i o hnyodfr oa xs ymp ruoclhi naes 3a8b4s o. 6rmp tgi oonf collagen hydrolysate per kg body weight. These finding suggest that ingestion of less than 30.8mg of collagen hydrolysate per body weight is not effective for health benefits. They also show that the dose is calculated taking account of body weight. Hence, doses may vary from one subject to another due to the variations of body weight. In this way, in order to maintain a ss iumb ji el acrt sd wo sheopreerc ke igv be do daydwa iel yi gdh ot sbee ot wf 1e 0e ng oa lf l sspuebcjief icct sf i, st hh ec o1l0l a0gkegn- peptides (Naticol ® ) should have received more than 10g/day compared to the ones who received 10g/day for a body weight eb qo ud iyv awl ee ni gthttow7a0skng o. Ht ee qr eu, i vt ha lee nd to sbee towf eceonl l aa gl lesnu hb yj edcrtos l ydsuaet et so pt he er huge body weight variations. However, all subjects received the minimum df oors eb eonf ecfoi tlsl a. gTehni shdy od sr eo l oy sf actoelsl argeepno rhtyeddr ob lyy sSahtiegse mi n ug reas teetd abl .y[ 2t h7e] st ou bdj ee cmt so nwsittrha tae vseirgyn hi fiigc ha nbt obdeynwe feiitgshat nwda sl anr eg ve er r bt heenleefsi st se ni no ut hg he active group. Conclusion This pilot clinical trial study, which consisted in a once daily treatment for 8 consecutive weeks, indicates that oral supplement specific fish collagen peptides have some interesting effects on knee osteoarthritis symptoms. The results demonstrated that daily oral doses of specific fish collagen peptides (Naticol ® ) in hr eedaul tchey psauibnj, e icmt sp wr oivt he qk un ae lei t yo s ot ef olai fret harni tdi s l ohwa se rt hbeo dpyo tfeunnt ci at il otno. Fmuorrteh earn ds t ua dhi ei gsh we ri tdho as ang ee xot ef npsrioodnu oc tf fdour rsaut ibojne cttos w1 2i twh eae kbso doyr weight greater than 70kg should be performed to confirm these preliminary results. Acknowledgments The study was funded by Weishardt International Group (France) which provided the fish collagen peptides (Naticol ® ) assessed in this study. References 1. B47u(c2k)w: a1l-t3e2r.JA, Martin J (1995) Degenerative joint disease. Clin Symp 2. Cr aodoipo eg rr aCp h(i2c 0k0n0e)e Ro si st ke ofaarctthorrist i sf o. Ar rtthher i ti inscRi dheenucme 4a n3 d( 5 )p: r9o9g 5r e- 1s s0i 0o 0n . o f 3. Zo shtoeuo aZrYt ,h rLiitui s YrKi s, kC:h ea n dHo sLe, Lrieus pFo(n2s0e1 4m)e Bt ao- da ny aml yas si ss. iOn db ee xs i tayn d( Ski lnveeer 4. S M p p e a r r r s i c n p h g e ) c L t 2 M i 2 v , e ( B 1 . B a 0 c a ) h : i l 2 m li 1 e e 8 r i e e 0 s r - 2 C C 1 l J i 8 n ( 5 1 R . 9 h9e7u)mEactoonlo1m1(ic4s):o8f 1o7s-t8eo3a4r. thritis: a global
5. AUrKt.hritis Care (2006) The impact of arthritis (statistics). Arthritis Care, 6. AArrtthhrriittiiss RReesseeaarcrchhUKU.K (2013) Osteoarthritis in general practise. 7. D( 2u0t 1e i6l )LS, pQeucei iflilce -nRaot uu rs as le lbCi o, aMc at iuvbe etrytpYe, E1s cdoalillaegJe, nB rpuenpot i- dBeosn on reat l Ci ,net ta ka el . reverse skin aging signs in mature women. Journal of Aging Research & Clinical Practice 5(2). 8. So af rt ah eS ,BMe naer ft ii cni aGl , ESf af ercaths Bo f, HR ay jdar oAl By s, eGde nC oo vl leasgee nL a( s2 0a 1N5u) t Ar anc eOuvtei cravli eown SNkuitnraPcreoupteicratilessJ:oSucrineanlti8f:ic2B9-a4c2k.ground and Clinical Studies. The Open 9. Mp eapt tsiuddea oNn, Kc oo yl laamg eanY,f iHb or isl as kaanYd ( g2l0y0c o6 s) aEmf fiencot sg loyfc ai nngse si nt i ot nh eo fdceorlml aigse. nJ Nutr Sci Vitaminol (Tokyo) 52(3): 211-215. 10. BE frfueyc èt roef cOo, l lZaeggeenl sh yBd, r Lo el yosnaot er i i nL ,a rRtai cbuelna dr ap aVi .n J: aan6s -sme no nAt ,h erta na dl . o(m2 0i z1e2d), d 12 ou 4 b -1 le 3 - 0 b . lind, placebo controlled study. Complement Ther Med 20(3): 11. C( 2l a0r0k0K) L2, 4S-eWb ea es tki asnt ue ldl yi Wo ,nF tl he ce hus seen ho af rc oKlRl a, gAeunk eh rymd raonl yn sDa tFe, Ma se zaa dFi, eet ta ar yl . sOuppinpl2e4m(e5n):t1in48a5th-1le4t9e6s.with activity-related joint pain. Curr Med Res 12. DO raar l QhAy ,d rMo al yyzneadr dt yRpDe , 1L icuo lZl a, gSecnh oi nt td uEcMe ,s Ccahtohnedl irnoer eSg, e ente raalt. i o( n2 0a1n6d) iOnsht ieboiat sr tshyrni toivs iCa la irnt ifllaagmem2 a4t(iSounpipn 1m) u: Sr i5n3e2p- So5s 3t t3r a. u m a t i c o s t e o a r t h r i t i s . 13. FOur dr ua zz a BwHa -, Ceatr ba al . l l(e2d0a1 2J , ) LPi oml ya mGe, r iLzleodr e- tnytpee LI, cNoul lña eg ze-nÁ ldvoa wr enz r eCg, uRl autiezs- isnyfml apmt omma at itoi cn kannede i mo spt reoovaerst h rciltiins i c af ol l l oo wu ticnogm easr t hi nr o spc aotpi ei cn t sl a vwa gi teh: aScireanntdifoicmWizoerdld, Joduorunballe2-b0l1in2d: ,34a2n8d54p.lacebo-controlled clinical trial. 1 4 . Hi nahri tboi gt sA z, Cy mo zoi jsnasne ni nMd ,udcee dV r ii nj Gf l ,aGmamr sastei no nJ . ( 2E0x1p3 )B Ci ool l l Ma geedn h( My daryowl yosoadt e) 238(7): 798-802. 15. K( 2u0m1 a5r) SA, dS ou ug bi hl ea -rba l iFn, dS, upzlua kc ei bKo, - Icnoonut er oNl l e, dV ,e rnaknadt eo smwi as er adt, hcilri nu ikcuaml satruad yS oAngrtihce95e(ff4e)c:t7iv0e2n-e7s0s7o. f collagen peptide on osteoarthritis. J Sci Food 16. Cohen J. Statistical Power Analysis for the Behaviorial Sciences Routledge ISBN 1-134-74270. 17. MM cc CMoansnt eerl l USn, iKv oe rl os pi tai ecsk OPs, tDe aovairst hArMi t i s( 2I 0n 0d 1e x) T( Wh eO WM Ae sCt)e: ran rOe nv iteawr i oo fa ni tds utility and measurement properties. Arthritis Rheum 45(5): 453-461. 18. Joef nt kh ien Ss oF n- 3 C6 , vSet re swi oa nr t 2- Bi rno twh ne US , nPi teet de rKs ei nng Sd, oPma .i cJ eE Cp i(d1e9m9 i9o)l AC os sme sms umnei nt yt Health 53(1): 46-50. 19. GV aólmi dei tzy J Fa, nCdu rrcei loi a Cb Li l ,i tAy l voafr at dh oe BS ,h Zo ur tn zPuhnyesgi cuai l MPVe, r fGour rma lanni cke J B( 2a t0t1e 3r y) (SPPB) Colomb Med (Cali) 44(3): 165-171. 20. AUmnievreircsaitnieCsoOllsetgeeoaorfthRrhiteisumInadteoxlo(gWy.OWMeAsCt)e.rn Ontario and McMaster 21. G( 1u9r 9a 4l n)i Ak sJ hMo, r St ipmh oy ns isciac lkp Ee rMf o, rFme rarnuccecbi aLt,t eGrlyy na sns eRsJs, i Bn ge rl ko mw ea rn e Lx tFr, eemt iat yl . fmu on rc tt ai ol int y: Aa ns sdonc ui artsi oi nng wh oi tmh es ea ldf -mr ei spsoi or tne. dJ oduirsna abli loi tf yG ae nr odn pt or leodgiyc t4i o9n( 2o) f: M85-M94. 22. SEunloliuvgahn. GJ MGr,aFdeiMnnedRE(d2u0c124)(3U)s:i2n7g9E-f2fe8c2t.Size-or Why the P Value Is Not
How to cite this article: Seán Lacey, Christelle Bonnet, Kelly Seamans, Andrea Doolan. Effect Size Statistics to Inform an Exploratory Analysis of a Double-Blinded, Randomised, Placebo Controlled Pilot Clinical Study to Evaluate the Efficacy of Naticol ® , Specific Fish Collagen Peptides to Alleviate Symptoms of Osteoarthritis in the Knee . JOJ Case Stud. 2019; 10(2): 555783. DOI: 10.19080/JOJCS.2019.10.555783 0036
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