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Figure 1: Effect size calculations on osteoarthritis related measurements from Baseline – Week 8 for (a) WOMAC scores; (b) SF-36v2; (c) SPPB. Table 5: Cohen’s d, within groups effect size calculations on osteoarthritis related measurements from baseline to Week 08. Measurements Placebo Active WOMAC Pain sub-scores 0.81 0.88 WOMAC Physical Function sub-scores 0.68 1.08 WOMAC Composite score during the study 0.82 1.07 SF-36v2 Role Limitations due to Physical Problems -0.51 -0.51 SF-36v2 Role Limitations due to Emotional Problems -0.44 -0.17 SF-36v2 0.07 -0.18 SF-36v2 0 -0.34 SF-36v2 0 -0.5 SF-36v2 0.15 -0.09 SPPB Balance Score 0 0 SPPB Chair Test Score -0.25 -0.47 SPPB Total score -0.1 -0.33
WOMAC Noting a higher score on the WOMAC indicates worse pain, ss ti zi fef n( eBsass, eal ni nde f –u nWc teieokn a8l) l ri me pi rt ae tsieonntss [a2n0 i]m. Hperno cvee ,ma epnot siint i vWe OeMf f eAcCt oP va ei nr ts hu eb -8s cwo er ee k, sb. oFt rho gmr oTuapbsl ee 5x p&e rFi ei gnucreed 1a( al )a, r wg ei t ihmt ph reo Wv eOmMe An tC, dt h =e p0 l. 8a c1e, b0o. 8 g8r, orue ps peexcpt ievrei el yn c[ 1e 6d ] a. Fsomr aWl l Oi mMpArCo vPehmy se inc ta l( dF u=n0c t. 6i o8n) af ogra it nh set Wt hOe Ma Ac tCi vCe ogmr opuops ’ist el asrcgoer ei mt hper opvl ae cme ebnot g(rdo u= p1 e. 0x8p)e. rFi ei nnaclel yd, ae v me ne dl ai ur gme r i mi mpprroovveemmeennt t ((dd == 10 .. 08 72 )) . aTghaei nWs tO tMh Ae Ca cs tt ii vf fen egsrso us upbs score is not presented Table 5 and Figure 1(a).
SF-36v2 Noting the lower the score the more disability [18]. Hence, ad i snaebgi laittiyv e( a ne f ifme cpt r os vi zeem e( Bn at )s eolvi ne er t h– e W8 ewe ek e k8s). Irne pt errems esnot sf Rl eosl es Limitations due to Physical Problems score, Role Limitations due to Emotional Problems score active group experienced medium improvements, see Table 5. Physical functioning, energy and vr ei tgaal ri tdy Ss oc oc irael s Faurne cnt ioot npi rnegs ea nn tde dP ai ni n Tsacbol ree5s , atnhde rFei gwu ar se n1 o( bc) h. Wa ni gt he inno st iccoerde af onr i tmh pe rpolvaecme beon tg rboyu ap s( dm =a l l0 .(0d0 =) , -w0h. 3i l4e) tahneda cmt ievdei ug mr o u( pd =a n-d0 . 5G0e)naemr aol uHn et ,arl tehsyp eIcstsi vueelsy. tFhi ne a pl l yl a, cf oe br oE-mb aostei odn as lu Wb j ee cl lt-sB edi ni sg-
How to cite this article: Seán Lacey, Christelle Bonnet, Kelly Seamans, Andrea Doolan. Effect Size Statistics to Inform an Exploratory Analysis of a Double-Blinded, Randomised, Placebo Controlled Pilot Clinical Study to Evaluate the Efficacy of Naticol ® , Specific Fish Collagen Peptides to Alleviate Symptoms of Osteoarthritis in the Knee . JOJ Case Stud. 2019; 10(2): 555783. DOI: 10.19080/JOJCS.2019.10.555783 0034
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