IBS Research and Probiotics
Stool samples were stored at –80ºC and analysed for presence/absence of the probiotic strains as an indicator of transit/washout of the probiotic strains and stored for microbiota diversity analysis, compositional analysis, SCFA analysis and metabolomics. The second studywas a randomized, double blinded, placebo-controlled study using a repeated measures cross-over design as outlined below. Volunteerswere screenedaccording to the selection criteria. Participantswere, between 18 and 55 years of age with IBS experiencing recurrent abdominal pain/discomfort andmild tomoderate stress/mood status. The study involved visits over a 28-week period. Thevolunteerswere randomised toGroup1orGroup2andunderwent a8-week intervention with either the investigational product or matching Placebo with a washout period between interventions. Further urine, saliva, blood and faecal samples were collected during the crossover study to assess similar endpoints in the pilot study.
atlantiaclinicaltrials.com
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