Assessing FMD in overweight adults

About the Study

Therefore, drink powders were dissolved in 500 mL of water shortly before consumption. The subjects were instructed to consume the citrus drinkwithin 10min after the T0 FMD. At 60 min (T1), 120 min (T2), and 180 min (T3) after the start of the citrus drink consumption, FMD scans and blood sample collections were performed. Ultrasound FMD scanning procedures were strictly standardized and quality controlled. In short, prior to the start of the study, two clinical trial assistants from Atlantia on site were trained and certified according to pre-set criteria of the FMD core lab (Imagelabonline & Cardiovascular, Erichem, The Netherlands). Validated

and FDA-approved image analysis software was used. All scans were performed with an Ultrasonix Sonix SP ultrasound instrument equipped with an L14-5MHz vascular transducer and fixed presets throughout the study. The examinations took place in a quiet room at temperatures between 20 °C and 26 °C and dimmed lighting. For each subject on both test days, initial and follow-up scans were performed by the same clinical trial assistant. Subjects comfortably reclined for 20 min prior to scans. A vein cannula was inserted into the subject’s left arm, and a blood sample (12 mL) was collected shortly after FMDmeasurement at T0, T1, T2, and T3 during both intervention days.

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