Assessing FMD in overweight adults

How Atlantia’s Solution Helped There are several techniques for assessing endothelial function. These techniques can be either invasive or non- invasive and assess different aspects of pathobiology. For the assessment of clinical pre-disease, the ideal technique for measuring endothelial function must be non-invasive, reliable, reproducible, cheap, and easy to perform . Atlantia was aware of the importance of the use of non- invasive techniques when assessing EF. It would be a critical factor when the study would be presented to the appropriated Ethics Committee following ICH GCP standards. EF can be assessed by brachial artery ultrasound imaging. With this completely non-invasive, subject-friendly technique, the shear stress-induced flow-mediated endothelium-dependent vasodilation (FMD) of the brachial artery can be measured. Brachial ultrasound FMD measurements are well reproducible and are considered a validated early marker of CVD risk. Atlantia’s expertise in cardiovascular human clinical studies (Figure 1) and their robust database of participants made the perfect fit for the Sponsor’s research needs.

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About the Study The present exploratory study aimed to investigate the acute effects of the investigational product versus those of placebo on endothelium-dependent vasodilation, i.e., FMD, in overweight/obese subjects.

atlantiaclinicaltrials.com