WOMEN HEALTH OBJECTIVE ENDPOINTS
INDICATION MEASUREMENT Cardiovascular health Blood Pressure (BP); Ambulatory BP; Endothelial function e.g. flow- mediated dilation (FMD)
Gastrointestinal health Physical Activity & performance Body Composition measurements
GI transit; bowel function; microbiome diversity Aerobic capacity/VO2 max; muscle max/strength % lean muscle, bone density, DEXA scan; Measurements: resting heart rate, weight, muscle circumference Amsel’s criteria and Nugent scoring system used as diagnostic method and primary outcomes evaluation, reduction in episodes of VI (compared to placebo), Severity of VI symptoms, Duration of VI symptoms, Microbiological profiling (Vaginal Microbiome) inflammatory biomarkers; plasma essential and non-essential amino acids, total protein, albumin, serum and urinary urea; plasma and salivary cortisol, IgA, tryptophan (stress indicators), creatinine; glucose; serum triglyceride; omega-3 fatty acids; oxidative stress measurements
Vaginal infections (VI) follow up
Biological Sample indicators
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