Clinical Endpoints
ENDPOINTS AND MEASUREMENTS
GASTROINTESTINAL HEALTH OBJECTIVE ENDPOINTS INDICATION MEASUREMENT Gut Functionality Function: oesophageal pH metry,
faecal weight and consistency; Transit time: radiopaque pellets; Permeability: lactulose-mannitol tracer test; Motility: gastric scintigraphy; VCE-Video Camera Endoscopy Epithelial integrity: histology, mucus secretion; Biomarkers: E-cadherin, growth factors, tight junction molecules, lipopolysaccharide (LPS) in blood, a-antitrypsin in faeces; Antimicrobial peptides: a-and b-defensins, calprotectin Immunoglobulins: IgA, IgE; Proteases: tryptase, chymase; Inflammatory cell signalling pathways: MAPK, NFkB, Cox 1 & 2; Inflammation: cytokines (Interleukins (IL) & TNFa), hsCRP, salivary cortisol, stool calprotectin
Gut Integrity
Immunity
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Inflammation
Microbiota
Shotgun sequencing, functional genomics, metabolomics, transcriptomics, GA-Map.
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