Henrotin et al. BMC Musculoskeletal Disorders
(2022) 23:650
Page 5 of 11
Table 1 Demographic and baseline characteristics (ITT population N = 198)) Placebo ( N = 68) 200 mg ( N = 66)
400 mg ( N = .64)
All ( N = 198)
P -values
Sex
n/n miss
68/0
66/0
64/0
198/0
0.52
Male, n(%)
25 (36.8%) 43(63.2%%)
28(42.4%) 38(57.6.%)
21(32.8%) 43 (67.2%)
74 (37.4%) 124 (62.6%)
Female, n(%)
Ethnicity
n/n miss
68/0
66/0
64/0
198/0
0.37
Asian, n(%) African, n(%)
0(0.0%) 0 (0.0%)
1(1.5%%)
0 (0.0%) 0 (0.0%)
1 (0.5%%)
0(0.0%)
0 (0.0%)
Caucasian, n(%)
68(100.0%)
65 (98.5%)
64 (100.0%)
197(99.5%)
Age (years)
n/n miss
68/0
66/0
64/0
198/0
0.21
Mean (SEM)
52.93 (1.39)
55.71 (1.21)
55.69 (1.25)
54.75 (0.75)
Median Min, Max n/n miss
52.50
54.50
56.60
55.00
30.0, 74.0
31.0, 75.0
35.0, 74.0
30.0, 75.0
BMI (kg/m 2 )
68/0
66/0
64/0
198/0
Mean (SEM)
27.16 (0.40)
26.70 (0.36)
26.88 (0.41)
26.92 (0.22)
Median Min, Max
27.49
26.60
26.49
26.69
0.70
20.10, 32.20 20 (29.4%) 32 (47.1%) 16 (23.5%)
19.96, 31.83 17 (25.8%) 38 (57.6%) 11 (16.7%)
19.06, 33.88 20 (31.3%) 31 (48.4%) 13(20.3%)
19.06, 33.88 57 (28.8%) 101 (51.0%) 40 (20.2%)
Normal [18.5—25[ Overweigth [25–30[ Obese ≥ 30
WOMAC global
n/n miss
68/0
66/0
64/0
198/0
0.81
Mean (SEM)
24.43 (1.68)
25.84(1.47)
24.80(1.58)
25.02 (0.91)
Median Min, Max n/n miss
20.83
26.04
23.44
22.92
3.1, 63.5
4.2, 55.2
6.3,56.3
3.1, 63.5
WOMAC pain
68/0
66/0
64/0
198/0
0.64
Mean (SEM)
4.66 (0.34)
5.14 (0.38)
4.87 (0.36)
4.89 (0.21)
Median Min, Max n/n miss
4.00
5.00
4.00
4.00
1.0, 14.0
0.0, 16.0
1.0, 12.0
0.0, 16.0
WOMAC stiffness
68/0
66/0
64/0
198/0
0.94
Mean (SEM)
2.71 (0.19)
2.77 (0.17)
2.78 (0.16)
2.75 (0.10)
Median Min, Max n/n miss
3.00
3.00
3.00
3.00
0.0, 6.0
0.0, 7.0
0.0, 5.0
0.0, 7.0 198/0
WOMAC function
68/0
66/0
64/0
0.86
Mean (SEM)
16.09 (1.19)
16.89 (1.02)
16.16 (1.18)
16.38 (0.65)
Median Min, Max n/n miss
13.00
17.00
15.00
15.00
2.0, 43.0
2.0, 39.0
1.0, 41.0
1.0, 43.0
VAS pain
68/0
66/0
64/0
198/0
0.97
Mean (SEM)
40.28 (2.15)
40.95 (2.29)
40.75 (2.04)
40.66 (1.24)
Median Min, Max n/n miss
40.00
40.00
40.00
40.00
10.0, 85.0
5.0, 80.0
10.0, 80.0
5.0, 85.0
SF36
67/1
66/0
64/0
197/1
0.68
Mean (SEM)
54.48 (17.90)
53.79 (20.68)
54.30 (19.70)
54.19 (19.35)
Median Min, Max
50.00
50.00
50.00
50.00
25.0, 100.0
25.0, 100.0
25.0, 100.0
25.0, 100.0
Walking test 20 m (s) n/n miss
68/0
66/0
64/0
198/0
0.51
Mean (SEM)
14.29 (0.25)
14.65 (0.22)
14.58 (0.22)
14.50 (0.14)
Median Min, Max
14.06
14.31
14.54
14.27
8.8, 22.2
11.3, 20.2
11.1, 19.9
8.8, 22.2
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