Henrotin et al. BMC Musculoskeletal Disorders
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Declarations
fruit peel extract reduces pain and stiffness and improves physical func‑ tion in adult patients with knee osteoarthritis. Nutr Res. 2010;30(9):601–6. 10. Bannuru RR, Schmid CH, Kent DM, Vaysbrot EE, Wong JB, McAlindon TE. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med. 2015;162(1):46–54. 11. Henrotin Y, Malaise M, Wittoek R, de Vlam K, Brasseur JP, Luyten FP, Jiangang Q, Van den Berghe M, Uhoda R, Bentin J, De Vroey T, Erpicum L, Donneau AF, Dierckxsens Y. Bio-optimized Curcuma longa extract is effi‑ cient on knee osteoarthritis pain: a double-blind multicenter randomized placebo-controlled three-arm study. Arthritis Res Ther. 2019;21(1):179–90. 12. Ludwig IA, Mena P, Calani L, Borges G, Pereira-Caro G, Bresciani L, Del Rio D, Lean ME, Crozier A. New insights into the bioavailability of red raspberry anthocyanins and ellagitannins. Free Radic Biol Med. 2015;89:758–69. Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in pub‑ lished maps and institutional affiliations.
Ethics approval and consent to participate The study protocol was approved by the Central Ethics Committee of The University College Cork, Irland (namely Clinical Research Ethics Committee), agreement number: ECM 4 (I) 07/02/17. The study participants signed written informed consents before participation in the study. Consent for publication An informed consent to published results has been obtained from all participants. Competing interests YH received consulting fees from Naturex and is the founder and president of Artialis SA. RT from Atlanstats and JMG supported statistical analysis. RLC and PB are employees of Naturex. GDG and AD are employees of Atlantia. MCS has no disclosed conflicts of interest. Author details 1 musculoSKeletal Innovative Research Lab (mSKIL), The Center for Interdis‑ ciplinary Research On Medicines (CIRM), Department of Motricity Center, Institute of Pathology, University of Liège, CHU Sart-Tilman, level 5, 4000 Liège, Belgium. 2 Department of Physical Therapy and Rehabilitation, Princess Paola Hospital, Vivalia, Marche‑en‑Famenne, Belgium. 3 Artialis SA, GIGA Tower, CHU Sart-Tilman, Avenue de l’hôpital, 4000 Liège, Belgium. 4 Naturex SA, Avignon, France. 5 Atlanstat SA, Les Espaces Océane, 3, rue Jules Verne, 44400 Rezé, France. 6 BIOSCAR Inserm U1132 and Department of Rheumatology, Université de Paris, Hôpital 10 Lariboisière, 75010 Paris, France. 7 Atlantia Clinical Trials, Heron House Offices, Blackpool T23 R50R, Cork, Ireland. 8 Department of Statis‑ tics, Rouen University, Rouen, France.
Received: 23 February 2022 Accepted: 30 June 2022
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